Endocrine Abstracts

Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific Familial dyslipidemia Unit and the effects on lipid profile in first months of treatment.Material and methods: Data from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors were reviewed. Clinical data, physical examination and analytical data were collected at baseline, one month and 3 months.Results: Da...

Introduction: A high percentage of patients diagnosed with Amyotrophic Lateral Sclerosis (ALS) have malnutrition. The nutritional treatment in ALS is essential, affecting muscle strength, quality of life and survival.Objective: To describe the nutritional characteristics of patients evaluated in a specific nutritional Unit in patients with ALS during 3 years.Material and methods: A descriptive study of all patients diagnosed with A...

Introduction: Acute pancreatitis induced by hypertriglyceridemia is a severe condition and its management is complicated.Case report: We present a case of severe acute pancreatitis induced by hypertriglyceridemia secondary to lipoprotein lipase -LPL- deficiency (188 Gly-Glu mutation, LPL undetectable activity) in a pregnant patient with gestational diabetes.The patient was sent to our Lipid Unit in the 13th gestation’ week. Th...

Objective: To determine the characteristics of patients with familiar hypercholesterolemia studied in a specific unit of lipids.Material and methods: A descriptive study of patients followed in our unit over the last 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH).Results: Data from 111 patients were analyzed: 66 with HFH and 45 with FCH.Featu...

Introduction: Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is underdiagnosed and appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents).Objective: To study features of patients with LADA diagnosed and treated in our clinic.Material and methods: Retrospective study of patients attended in our clinic in ...

Introduction: Vitamin D deficiency is very common in our population.It is not clear which is the most effective vitamin D dosing regimen in patients with deficiency.Objective: To compare two vitamin D supplementation regimen in patients with vitamin D deficiency.Material and methods: This is an interventional study: Patients atended in our clinic during May and June 2017 with 25-Hydroxyvitamin D below 30 ng/ml were consecutively se...

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

Introduction: Cushing disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone–secreting pituitary tumor. Inadequately treated CD is associated with significant morbidity and elevated mortality.Objetive: The study purpose was to describe the long term treatment outcomes for CD patients in our hospital.Methods: Retrospective analysis of the records of 36 patients with Cushing dise...

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

Introduction: Hydroxymethylglutaric aciduria is a rare metabolic disease that is caused by the deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase, which participates in the metabolism of leucine and in the formation of ketone bodies. The symptomatology usually occurs in the first two years of life and consists of nausea, vomiting, diarrhea, hypotoniaanddepressed level of consciousness. Metabolic acidosis occurs during crises as a result of the accumulation of metabo...